In vitro effect of free and complexed indium(III) against Mycobacterium tuberculosis.
Identifieur interne : 002D47 ( Main/Exploration ); précédent : 002D46; suivant : 002D48In vitro effect of free and complexed indium(III) against Mycobacterium tuberculosis.
Auteurs : RBID : pubmed:16137841English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Arsenic (pharmacology), Bismuth (pharmacology), Colony Count, Microbial, Indium (pharmacology), Iron (pharmacology), Microbial Sensitivity Tests, Mycobacterium tuberculosis (drug effects), Mycobacterium tuberculosis (growth & development), Vanadium (pharmacology).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents, Arsenic, Bismuth, Indium, Iron, Vanadium.
- drug effects : Mycobacterium tuberculosis.
- growth & development : Mycobacterium tuberculosis.
- Colony Count, Microbial, Microbial Sensitivity Tests.
Abstract
In mycobacteria, the study of inhibition by metal ions has been limited by the absence of suitable molecular vectors. Recently, we reported on the inhibitory activity of a family of chelators, macrocyclic compounds (MCC), against Mycobacterium tuberculosis. In this study equimolar concentrations of the free cations vanadium(IV), arsenic(III), iron(III), indium(III) and bismuth(III), and as 1:1 complexes with the MCC 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetra-acetic acid (TETA) were tested in vitro against M. tuberculosis using the Bactec 460 TB radiometric technology (Becton-Dickinson, MD, USA). Radiometric inhibition above 80% was obtained with free indium(III) and bismuth(III), and ranged from 80% to 99%, with the complexes of TETA with vanadium(IV), bismuth(III) and indium(III), in the order of increasing activity. The highest radiometric inhibition levels were obtained with the [In(TETA)]- complex, which caused drops of up to 4 log units in cellular viability. The minimal inhibitory concentration of this compound was evaluated at 3 microM.
DOI: 10.1016/j.femsle.2005.07.044
PubMed: 16137841
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vitro effect of free and complexed indium(III) against Mycobacterium tuberculosis.</title><author><name sortKey="David, Suzana" uniqKey="David S">Suzana David</name><affiliation wicri:level="1"><nlm:affiliation>Mycobacteriology Unit, Instituto de Higiéne e Medicina Tropical, Universidade Nova de Lisboa (UNL), Rua da Junqueira 96, 1349-008, Lisbon, Portugal. suzanadavid@ihmt.unl.pt</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Mycobacteriology Unit, Instituto de Higiéne e Medicina Tropical, Universidade Nova de Lisboa (UNL), Rua da Junqueira 96, 1349-008, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Barros, Vanessa" uniqKey="Barros V">Vanessa Barros</name></author><author><name sortKey="Cruz, Carla" uniqKey="Cruz C">Carla Cruz</name></author><author><name sortKey="Delgado, Rita" uniqKey="Delgado R">Rita Delgado</name></author></titleStmt><publicationStmt><date when="2005">2005</date><idno type="doi">10.1016/j.femsle.2005.07.044</idno><idno type="RBID">pubmed:16137841</idno><idno type="pmid">16137841</idno><idno type="wicri:Area/Main/Corpus">002E00</idno><idno type="wicri:Area/Main/Curation">002E00</idno><idno type="wicri:Area/Main/Exploration">002D47</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (pharmacology)</term><term>Arsenic (pharmacology)</term><term>Bismuth (pharmacology)</term><term>Colony Count, Microbial</term><term>Indium (pharmacology)</term><term>Iron (pharmacology)</term><term>Microbial Sensitivity Tests</term><term>Mycobacterium tuberculosis (drug effects)</term><term>Mycobacterium tuberculosis (growth & development)</term><term>Vanadium (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Arsenic</term><term>Bismuth</term><term>Indium</term><term>Iron</term><term>Vanadium</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Colony Count, Microbial</term><term>Microbial Sensitivity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In mycobacteria, the study of inhibition by metal ions has been limited by the absence of suitable molecular vectors. Recently, we reported on the inhibitory activity of a family of chelators, macrocyclic compounds (MCC), against Mycobacterium tuberculosis. In this study equimolar concentrations of the free cations vanadium(IV), arsenic(III), iron(III), indium(III) and bismuth(III), and as 1:1 complexes with the MCC 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetra-acetic acid (TETA) were tested in vitro against M. tuberculosis using the Bactec 460 TB radiometric technology (Becton-Dickinson, MD, USA). Radiometric inhibition above 80% was obtained with free indium(III) and bismuth(III), and ranged from 80% to 99%, with the complexes of TETA with vanadium(IV), bismuth(III) and indium(III), in the order of increasing activity. The highest radiometric inhibition levels were obtained with the [In(TETA)]- complex, which caused drops of up to 4 log units in cellular viability. The minimal inhibitory concentration of this compound was evaluated at 3 microM.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16137841</PMID><DateCreated><Year>2005</Year><Month>09</Month><Day>19</Day></DateCreated><DateCompleted><Year>2006</Year><Month>03</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0378-1097</ISSN><JournalIssue CitedMedium="Print"><Volume>251</Volume><Issue>1</Issue><PubDate><Year>2005</Year><Month>Oct</Month><Day>1</Day></PubDate></JournalIssue><Title>FEMS microbiology letters</Title><ISOAbbreviation>FEMS Microbiol. Lett.</ISOAbbreviation></Journal><ArticleTitle>In vitro effect of free and complexed indium(III) against Mycobacterium tuberculosis.</ArticleTitle><Pagination><MedlinePgn>119-24</MedlinePgn></Pagination><Abstract><AbstractText>In mycobacteria, the study of inhibition by metal ions has been limited by the absence of suitable molecular vectors. Recently, we reported on the inhibitory activity of a family of chelators, macrocyclic compounds (MCC), against Mycobacterium tuberculosis. In this study equimolar concentrations of the free cations vanadium(IV), arsenic(III), iron(III), indium(III) and bismuth(III), and as 1:1 complexes with the MCC 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetra-acetic acid (TETA) were tested in vitro against M. tuberculosis using the Bactec 460 TB radiometric technology (Becton-Dickinson, MD, USA). Radiometric inhibition above 80% was obtained with free indium(III) and bismuth(III), and ranged from 80% to 99%, with the complexes of TETA with vanadium(IV), bismuth(III) and indium(III), in the order of increasing activity. The highest radiometric inhibition levels were obtained with the [In(TETA)]- complex, which caused drops of up to 4 log units in cellular viability. The minimal inhibitory concentration of this compound was evaluated at 3 microM.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>David</LastName><ForeName>Suzana</ForeName><Initials>S</Initials><Affiliation>Mycobacteriology Unit, Instituto de Higiéne e Medicina Tropical, Universidade Nova de Lisboa (UNL), Rua da Junqueira 96, 1349-008, Lisbon, Portugal. suzanadavid@ihmt.unl.pt</Affiliation></Author><Author ValidYN="Y"><LastName>Barros</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Cruz</LastName><ForeName>Carla</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Rita</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>FEMS Microbiol Lett</MedlineTA><NlmUniqueID>7705721</NlmUniqueID><ISSNLinking>0378-1097</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>00J9J9XKDE</RegistryNumber><NameOfSubstance>Vanadium</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>E1UOL152H7</RegistryNumber><NameOfSubstance>Iron</NameOfSubstance></Chemical><Chemical><RegistryNumber>N712M78A8G</RegistryNumber><NameOfSubstance>Arsenic</NameOfSubstance></Chemical><Chemical><RegistryNumber>U015TT5I8H</RegistryNumber><NameOfSubstance>Bismuth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Arsenic</DescriptorName><QualifierName MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Bismuth</DescriptorName><QualifierName MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Colony Count, Microbial</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Iron</DescriptorName><QualifierName MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mycobacterium tuberculosis</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Vanadium</DescriptorName><QualifierName MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>5</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>7</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>7</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>9</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>3</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>9</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0378-1097(05)00551-3</ArticleId><ArticleId IdType="doi">10.1016/j.femsle.2005.07.044</ArticleId><ArticleId IdType="pubmed">16137841</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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